Cannabidiol (CBD) and cognitive function in older adults: a mini review

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Authors
Binkowska, Alicja Anna
Mateja, Agnieszka
Jakubowska, Natalia
Monograph
Monograph (alternative title)
Date
2025-08-28
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Frontiers in Psychiatry
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16
Pages
Pages
1-6
DOI
ISSN
1664-0640
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https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1646151/full
Access date
2025-08-28
Abstract PL
Abstract EN
As the global population ages, the need for effective interventions to support cognitive health in older adults is growing. Cannabidiol (CBD), a non-intoxicating component of cannabis, has emerged as a potential neuroprotective agent due to its anti-inflammatory, antioxidant, and anxiolytic properties. While preclinical studies show promising effects on hippocampal neurogenesis and cognitive performance, human trials remain limited, particularly in older populations. Existing studies have focused primarily on young, healthy adults and acute administration, often using oral routes that yield low and variable bioavailability. Furthermore, the endocannabinoid system undergoes age-related changes, potentially altering CBD efficacy in older adults. This review synthesizes current evidence on CBD and cognitive function, emphasizing age as a moderating factor, exploring pharmacokinetic challenges, and identifying key research gaps. The review calls for well-controlled trials in older adults using standardized cognitive measures, neuroimaging, and biomarker assessments. Understanding the age-specific impact of CBD on cognition is essential for evaluating its therapeutic potential in an aging society.
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Keywords PL
Keywords EN
cannabidiol
CBD
cognitive aging
neuroprotection
endocannabinoid system
older adults
cognition
aging
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https://share.swps.edu.pl/handle/swps/1717
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cc-by
Except as otherwise noted, this item is licensed under the Attribution licence | Permitted use of copyrighted works
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