Cannabidiol (CBD) and cognitive function in older adults: a mini review

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cris.lastimport.scopus2025-09-02T03:16:43Z
dc.abstract.enAs the global population ages, the need for effective interventions to support cognitive health in older adults is growing. Cannabidiol (CBD), a non-intoxicating component of cannabis, has emerged as a potential neuroprotective agent due to its anti-inflammatory, antioxidant, and anxiolytic properties. While preclinical studies show promising effects on hippocampal neurogenesis and cognitive performance, human trials remain limited, particularly in older populations. Existing studies have focused primarily on young, healthy adults and acute administration, often using oral routes that yield low and variable bioavailability. Furthermore, the endocannabinoid system undergoes age-related changes, potentially altering CBD efficacy in older adults. This review synthesizes current evidence on CBD and cognitive function, emphasizing age as a moderating factor, exploring pharmacokinetic challenges, and identifying key research gaps. The review calls for well-controlled trials in older adults using standardized cognitive measures, neuroimaging, and biomarker assessments. Understanding the age-specific impact of CBD on cognition is essential for evaluating its therapeutic potential in an aging society.
dc.affiliationWydział Psychologii w Warszawie
dc.contributor.authorBinkowska, Alicja Anna
dc.contributor.authorMateja, Agnieszka
dc.contributor.authorJakubowska, Natalia
dc.date.access2025-08-28
dc.date.accessioned2025-08-29T06:22:57Z
dc.date.available2025-08-29T06:22:57Z
dc.date.created2025-07-30
dc.date.issued2025-08-28
dc.description.accesstimeat_publication
dc.description.physical1-6
dc.description.versionfinal_published
dc.description.volume16
dc.identifier.doi10.3389/fpsyt.2025.1646151
dc.identifier.issn1664-0640
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1717
dc.identifier.weblinkhttps://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1646151/full
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.rights.urihttps://creativecommons.org/licenses/by/3.0
dc.share.articleOPEN_JOURNAL
dc.subject.encannabidiol
dc.subject.enCBD
dc.subject.encognitive aging
dc.subject.enneuroprotection
dc.subject.enendocannabinoid system
dc.subject.enolder adults
dc.subject.encognition
dc.subject.enaging
dc.swps.sciencecloudsend
dc.titleCannabidiol (CBD) and cognitive function in older adults: a mini review
dc.title.journalFrontiers in Psychiatry
dc.typeJournalArticle
dspace.entity.typeArticle