Anhedonia in bipolar depression treated with ketamine

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cris.lastimport.scopus2025-08-29T03:11:55Z
dc.abstract.enBackground: Bipolar depression is the major cause of morbidity in patients with bipolar disorder. It affects psychosocial functioning and markedly impairs occupational productivity. Anhedonia is one of the most debilitating symptoms of depression contributing to treatment resistance. It correlates with suicidality, low quality of life, social withdrawal, and poor treatment response. Currently, there is no approved treatment specifically targeting anhedonia. Emerging evidence suggests that ketamine possesses anti-anhedonic properties in individuals with depression. Objectives: The aim of this naturalistic open-label study was to investigate the effect of add-on ketamine treatment on anhedonia in treatment resistant bipolar depression. Methods: Our main interest was the change in patient-reported (Snaith-Hamilton Pleasure Scale) and rater-based anhedonia measure (Montgomery–Åsberg Depression Rating Scale-anhedonia subscale). The secondary aim was to analyze the score change in three Inventory of Depressive Symptomatology-Self Report (IDS-SR) domains: mood/cognition, anxiety/somatic, and sleep. Patients underwent assessments at several time points, including baseline, after the third, fifth, and seventh ketamine infusions. Additionally, a follow-up assessment was conducted 1 week following the final ketamine administration. Results: We found improvement in anhedonia symptoms according to both patient-reported and rater-based measures. The improvement in IDS-SR domains was most prominent in anxiety/somatic factor and mood/cognition factor, improvement in sleep factor was not observed. No serious adverse events occurred. Conclusion: Add-on ketamine seems to be a good choice for the treatment of anhedonia in treatment resistant bipolar depression. It also showed a good effect in reducing symptoms of anxiety in this group of patients. Considering unmet needs and the detrimental effect of anhedonia and anxiety, more studies are needed on ketamine treatment in resistant bipolar depression.
dc.affiliationWydział Psychologii w Sopocie
dc.affiliationInstytut Psychologii
dc.contributor.authorArciszewska-Leszczuk, Aleksandra
dc.contributor.authorWilkowska, Alina
dc.contributor.authorWiglusz, Mariusz S.
dc.contributor.authorGałuszko-Węgielnik, Maria
dc.contributor.authorCubała, Wiesław J.
dc.date.access2024-02-04
dc.date.accessioned2024-06-18T10:42:35Z
dc.date.available2024-02-13T13:17:32Z
dc.date.created2024-01-25
dc.date.issued2024-02-04
dc.description.accesstimebefore_publication
dc.description.grantnumber01-10024/ 0006051/01/221/0/2024
dc.description.issue4
dc.description.physical356-363
dc.description.versionfinal_published
dc.description.volume26
dc.identifier.doi10.1111/bdi.13409
dc.identifier.eissn1399-5618
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/462.2
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/full/10.1111/bdi.13409
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsClosedAccess
dc.rights.explanationArtykuł za paywallem
dc.rights.questionNo_rights
dc.share.articleOTHER
dc.subject.enanhedonia
dc.subject.enanxiety
dc.subject.enketamine IDS- SR domains
dc.subject.ensleep
dc.subject.entreatment resistant bipolar depression
dc.swps.sciencecloudsend
dc.titleAnhedonia in bipolar depression treated with ketamine
dc.title.journalBipolar Disorders
dc.typeJournalArticle
dspace.entity.typeArticle

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