Choroid Plexus MRI Features and Cognitive Outcomes in Multiple Sclerosis: A Scoping Review

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dc.abstract.enBackground/Objectives: Multiple sclerosis (MS) is frequently accompanied by cognitive impairment, yet the neurobiological mechanisms underlying cognitive heterogeneity remain incompletely understood. The choroid plexus (CP), a blood–CSF barrier structure involved in cerebrospinal fluid production and neuroimmune signaling, has recently emerged as a potential MRI marker of inflammatory and neurodegenerative activity in MS. This scoping review mapped evidence on associations between CP features and cognitive functions in adults with MS. Methods: A broad search of PubMed, Scopus, Web of Science Core Collection, and the Cochrane Library identified 1163 records; after deduplication, screening, and full-text assessment, seven studies were included. Results: CP volume or normalized CP volume was assessed in all seven studies, and one study additionally examined the CP T1/T2 ratio. The Symbol Digit Modalities Test was used in six studies, while five applied multidomain cognitive assessment. Larger CP volume was associated in several studies with poorer baseline information-processing speed, visuospatial memory, or multidomain cognition, but longitudinal findings did not show consistent predictive value for CP volume. One study reported that a higher CP T1/T2 ratio predicted faster visuospatial-memory decline. Conclusions: CP-related measures may reflect broader neuroinflammatory and neurodegenerative processes relevant to cognition in MS, but the evidence remains limited and methodologically heterogeneous. Standardized acquisition and segmentation, harmonized cognitive assessment, and adequately powered longitudinal studies are needed to establish their independent and predictive value.
dc.affiliationFaculty of Psychology
dc.affiliationWydział Psychologii w Katowicach
dc.contributor.authorGalus, Weronika
dc.contributor.authorRomaniszyn-Kania, Patrycja
dc.contributor.authorUrantówka, Aleksandra
dc.contributor.authorZielonka, Hanna
dc.contributor.authorZawiślak-Fornagiel, Katarzyna
dc.contributor.authorWyszomirska, Julia
dc.contributor.authorKłosińska, Urszula
dc.contributor.authorBożek, Oskar
dc.contributor.authorLedwoń, Daniel
dc.contributor.authorTuszy, Aleksandra
dc.contributor.authorMitas, Andrzej W.
dc.contributor.authorSiuda, Joanna
dc.date.access2026-08-04
dc.date.accessioned2026-09-07T08:07:02Z
dc.date.available2026-09-07T08:07:02Z
dc.date.created2026-08-03
dc.date.issued2026
dc.description.abstract<jats:p>Background/Objectives: Multiple sclerosis (MS) is frequently accompanied by cognitive impairment, yet the neurobiological mechanisms underlying cognitive heterogeneity remain incompletely understood. The choroid plexus (CP), a blood–CSF barrier structure involved in cerebrospinal fluid production and neuroimmune signaling, has recently emerged as a potential MRI marker of inflammatory and neurodegenerative activity in MS. This scoping review mapped evidence on associations between CP features and cognitive functions in adults with MS. Methods: A broad search of PubMed, Scopus, Web of Science Core Collection, and the Cochrane Library identified 1163 records; after deduplication, screening, and full-text assessment, seven studies were included. Results: CP volume or normalized CP volume was assessed in all seven studies, and one study additionally examined the CP T1/T2 ratio. The Symbol Digit Modalities Test was used in six studies, while five applied multidomain cognitive assessment. Larger CP volume was associated in several studies with poorer baseline information-processing speed, visuospatial memory, or multidomain cognition, but longitudinal findings did not show consistent predictive value for CP volume. One study reported that a higher CP T1/T2 ratio predicted faster visuospatial-memory decline. Conclusions: CP-related measures may reflect broader neuroinflammatory and neurodegenerative processes relevant to cognition in MS, but the evidence remains limited and methodologically heterogeneous. Standardized acquisition and segmentation, harmonized cognitive assessment, and adequately powered longitudinal studies are needed to establish their independent and predictive value.</jats:p>
dc.description.accesstimeat_publication
dc.description.issue8
dc.description.physical1-15
dc.description.sdgGoodHealthAndWellBeing
dc.description.versionfinal_published
dc.description.volume16
dc.identifier.doi10.3390/brainsci16080829
dc.identifier.issn2076-3425
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/2511
dc.identifier.weblinkhttps://www.mdpi.com/2076-3425/16/8/829
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.subject.enmultiple sclerosis
dc.subject.enchoroid plexus
dc.subject.encognitive impairment
dc.subject.encognitive function
dc.subject.enscoping review
dc.subject.enneuroinflammation
dc.subject.enmagnetic resonance imaging
dc.subject.enchoroid plexus volume
dc.subject.ensymbol digit modalities test
dc.swps.sciencecloudsend
dc.titleChoroid Plexus MRI Features and Cognitive Outcomes in Multiple Sclerosis: A Scoping Review
dc.title.journalBrain Sciences
dc.typeJournalArticle
dspace.entity.typeArticle