Choroid Plexus MRI Features and Cognitive Outcomes in Multiple Sclerosis: A Scoping Review

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Authors
Galus, Weronika
Romaniszyn-Kania, Patrycja
Urantówka, Aleksandra
Zielonka, Hanna
Zawiślak-Fornagiel, Katarzyna
Wyszomirska, Julia
Kłosińska, Urszula
Bożek, Oskar
Ledwoń, Daniel
Tuszy, Aleksandra
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Date
2026
Publisher
Journal title
Brain Sciences
Issue
8
Volume
16
Pages
Pages
1-15
DOI
ISSN
2076-3425
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https://www.mdpi.com/2076-3425/16/8/829
Access date
2026-08-04
Abstract PL
Abstract EN
Background/Objectives: Multiple sclerosis (MS) is frequently accompanied by cognitive impairment, yet the neurobiological mechanisms underlying cognitive heterogeneity remain incompletely understood. The choroid plexus (CP), a blood–CSF barrier structure involved in cerebrospinal fluid production and neuroimmune signaling, has recently emerged as a potential MRI marker of inflammatory and neurodegenerative activity in MS. This scoping review mapped evidence on associations between CP features and cognitive functions in adults with MS. Methods: A broad search of PubMed, Scopus, Web of Science Core Collection, and the Cochrane Library identified 1163 records; after deduplication, screening, and full-text assessment, seven studies were included. Results: CP volume or normalized CP volume was assessed in all seven studies, and one study additionally examined the CP T1/T2 ratio. The Symbol Digit Modalities Test was used in six studies, while five applied multidomain cognitive assessment. Larger CP volume was associated in several studies with poorer baseline information-processing speed, visuospatial memory, or multidomain cognition, but longitudinal findings did not show consistent predictive value for CP volume. One study reported that a higher CP T1/T2 ratio predicted faster visuospatial-memory decline. Conclusions: CP-related measures may reflect broader neuroinflammatory and neurodegenerative processes relevant to cognition in MS, but the evidence remains limited and methodologically heterogeneous. Standardized acquisition and segmentation, harmonized cognitive assessment, and adequately powered longitudinal studies are needed to establish their independent and predictive value.
Abstract other
Keywords PL
Keywords EN
multiple sclerosis
choroid plexus
cognitive impairment
cognitive function
scoping review
neuroinflammation
magnetic resonance imaging
choroid plexus volume
symbol digit modalities test
Keywords other
Sustainable Development Goals
SDG 3. Good Health and Well-being
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https://share.swps.edu.pl/handle/swps/2511
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Except as otherwise noted, this item is licensed under the Attribution licence | Permitted use of copyrighted works
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