When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants

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Authors
Chrobak, Adrian Andrzej
Siuda-Krzywicka, Katarzyna
Soltys, Zbigniew
Bielak, Sylwia
Nowaczek, Dominik
Żyrkowska, Aleksandra
Fafrowicz, Magdalena
Marek, Tadeusz
Pęcherzewska, Ewa
Kużdżał, Jan
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Date
2023-09-12
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Frontiers in Psychiatry
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14
Pages
Pages
1-11
DOI
ISSN
1664-0640
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https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1238473/full
Access date
2023-09-12
Abstract PL
Abstract EN
Introduction: Our previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SRTT), prepared for use in the MRI. Methods: This study involved 186 participants. A total of 97 participants (33 BD, 33 SZ, and 31 healthy controls, HCs) completed the original, unlimited time response variant of SRTT. A total of 90 individuals (30 BD, 30 SZ, and 30 HCs) underwent a newer, limited response time version of this procedure. Results: There was no significant difference in terms of implicit motor learning indices between both limited and unlimited response time SRTT. Compared to HCs, SZ, and BD patients presented decreased indices of implicit motor learning. Both clinical groups showed a paradoxical learning pattern that differed significantly from the HCs. Moreover, in the SZ group, the pattern depended on the hand performing SRTT. Discussion: The limited response time SRTT variant allowed us to replicate the findings of disrupted implicit motor learning in SZ and BD. The use of this paradigm in further neuroimaging studies may help to determine the neuronal underpinnings of this cognitive dysfunction in the abovementioned clinical groups.
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Keywords EN
motor functions
movement disorders
cognition
cerebellum
procedural learning
affective disorders
sequence learning
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https://share.swps.edu.pl/handle/swps/231
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Except as otherwise noted, this item is licensed under the Attribution licence | Permitted use of copyrighted works
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