The effect of an online acceptance and commitment intervention on the meaning-making process in cancer patients following hematopoietic cell transplantation: Study protocol for a randomized controlled trial enhanced with single-case experimental design

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cris.lastimport.scopus2025-05-08T03:14:34Z
dc.abstract.enBackground: Hematopoietic cell transplantation (HCT) is a highly invasive and life-threatening treatment for hematological neoplasms and some types of cancer that can challenge the patient's meaning structures. Restoring meaning (i.e. building more flexible and significant explanations of the disease and treatment burden) can be aided by strengthening psychological flexibility by means of an Acceptance and Commitment Therapy (ACT) intervention. Thus, this trial aims to examine the effect of the ACT intervention on the meaning-making process and the underlying mechanisms of change in patients following HCT compared to a minimally enhanced usual care (mEUC) control group. The trial will be enhanced with a single-case experimental design (SCED), where ACT interventions will be compared between individuals with various pre-intervention intervals. Methods: In total, 192 patients who qualify for the first autologous or allogeneic HCT will be recruited for a two-armed parallel randomized controlled trial comparing an online self-help 14-day ACT training to education sessions (recommendations following HCT). In both conditions, participants will receive once a day a short survey and intervention proposal (about 5-10 minutes a day) in the outpatient period. Double-blinded assessment will be conducted at baseline, during the intervention, immediately, 1 month, and 3 months after the intervention. In addition, 6-9 participants will be invited to SCED and randomly assigned to pre-intervention measurement length (1-3 weeks) before completing ACT intervention, followed by 7-day observations at the 2nd and 3rd post-intervention measure. The primary outcome is meaning-related distress. Secondary outcomes include psychological flexibility, meaning-making coping, meanings made, well-being, as well as global and situational meaning. Discussion: This trial represents the first study that integrates the ACT and meaning-making frameworks to reduce meaning-related distress, stimulate the meaning-making process, and enhance the well-being of HCT recipients. Testing of an intervention to address existential concerns unique to patients undergoing HCT will be reinforced by a statistically rigorous idiographic approach to see what works for whom and when. Since access to interventions in the HCT population is limited, the web-based ACT self-help program could potentially fill this gap.
dc.affiliationWydziaƂ Psychologii w Warszawie
dc.affiliationInstytut Psychologii
dc.contributor.authorKroemeke, Aleksandra
dc.contributor.authorDudek, Joanna
dc.contributor.authorKijowska, Marta
dc.contributor.authorOwen, Ray
dc.contributor.authorSobczyk-Kruszelnicka, MaƂgorzata
dc.date.access2024-06-18
dc.date.accessioned2024-06-19T12:10:09Z
dc.date.available2024-06-19T12:10:09Z
dc.date.created2024-06-10
dc.date.issued2024-06-18
dc.description.accesstimeat_publication
dc.description.additionalvorPublikacja ukazaƂa się w numerze. Nietety, nie widzę, jak wprowadzić tu numer, doi, itp.
dc.description.grantnumber2020/39/B/HS6/01927
dc.description.granttitleProces przywracania znaczenia w chorobie nowotworowej: rola elastycznoƛci psychologicznej. Badania intensywne podƂuĆŒne i eksperymentalne
dc.description.physical1-18
dc.description.versionfinal_published
dc.description.volume25
dc.identifier.doi10.1186/s13063-024-08235-1
dc.identifier.issn1745-6215
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/716
dc.identifier.weblinkhttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08235-1
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.subject.enmeaning-making
dc.subject.enmeanings made
dc.subject.enwell-being
dc.subject.enacceptance and commitment therapy
dc.subject.encancer
dc.subject.enhematopoietic cell transplantation
dc.subject.enrandomized controlled trial
dc.subject.ensingle-case experimental design
dc.swps.sciencecloudsend
dc.titleThe effect of an online acceptance and commitment intervention on the meaning-making process in cancer patients following hematopoietic cell transplantation: Study protocol for a randomized controlled trial enhanced with single-case experimental design
dc.title.journalTrials
dc.typeJournalArticle
dspace.entity.typeArticle