EEG-based network dynamics in cannabis and polydrug use: a directed transfer function approach
EEG-based network dynamics in cannabis and polydrug use: a directed transfer function approach
StatusVoR
Alternative title
Authors
Binkowska, Alicja Anna
Kaszyńska, Anna
Kamiński, Maciej
Blinowska, Katarzyna
Czarny, Jakub
Raczkowski, Michał
Brzezicka, Aneta
Monograph
Monograph (alternative title)
Date
2025-10-20
Publisher
Journal title
Psychopharmacology
Issue
Volume
Pages
Pages
ISSN
0033-3158
ISSN of series
Access date
2025-12-08
Abstract PL
Abstract EN
Rationale and Objectives Cannabis is often consumed in polysubstance contexts, yet research comparing its isolated use to polydrug use is limited. Such comparisons are essential for understanding substance‑specific versus interactive effects on brain activity. This study investigates how cannabis‑only and polydrug use relate to alterations in resting‑state EEG functional connectivity, using the Directed Transfer Function (DTF) to assess frequency‑specific information flow in the brain. Methods Three age‑ and sex‑matched groups were studied: individuals with cannabis‑only use (n=27), polydrug use (n=29),
and non‑drug‑using controls (n=30). Resting‑state EEG was recorded under eyes‑open and eyes‑closed conditions. DTF was applied to quantify directed connectivity and frequency‑dependent propagation of neural signals across brain regions. Results Individuals with cannabis‑only use exhibited localized changes in neural propagation, particularly in frontal areas and within theta, beta, and gamma bands, while alpha‑band activity remained relatively stable. In contrast, individuals with polydrug use showed more widespread and complex alterations in connectivity, including reduced alpha activity and increased frontal and prefrontal engagement, suggesting heightened excitation and possible compensatory mechanisms. Conclusions This study is the first to characterize frequency‑specific EEG connectivity patterns associated with cannabis and polydrug use. The findings highlight the importance of studying substance use patterns and considering cannabis within a polysubstance context. A longitudinal study is needed to assess the effects of use duration, frequency, and dosage.
Abstract other
Keywords PL
Keywords EN
Directed functional connectivity
Cannabis
Drug use
Polydrug use
Directed Transfer Function (DTF)
Resting‑state EEG
Cannabis
Drug use
Polydrug use
Directed Transfer Function (DTF)
Resting‑state EEG
Keywords other
Sustainable Development Goals
Exhibition title
Place of exhibition (institution)
Exhibition curator
Type
License type
Funder
Time range from
Time range to
Contact person name
Related publication
Related publication
Grant/project name
Collections
Views
8Acquisition Date16.12.2025
Downloads
1Acquisition Date16.12.2025
Altmetrics©
Dimensions
Google Scholar
