Tracing diurnal differences in brain anatomy with voxel-based morphometry - associations with sleep characteristics

StatusVoR
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Authors
Zaręba, Michał Rafał
Fafrowicz, Magdalena
Marek, Tadeusz
Ogińska, Halszka
Beldzik, Ewa
Domagalik, Aleksandra
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Date
2024-01-08
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Chronobiology International
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2
Volume
41
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201–212
ISSN
0742-0528
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Multiple aspects of brain functioning, including arousal, motivation, and cognitive performance, are governed by circadian rhythmicity. Although the recent rise in the use of magnetic resonance imaging (MRI) has enabled investigations into the macroscopic correlates of the diurnal brain processes, neuroanatomical studies are scarce. The current work investigated how time-of-day (TOD) impacts white (WM) and grey matter (GM) volumes using voxel-based morphometry (VBM) in a large dataset (N = 72) divided into two equal, comparable subsamples to assess the replicability of effects. Furthermore, we aimed to assess how the magnitude of these diurnal differences was related to actigraphy-derived indices of sleep health. The results extend the current knowledge by reporting that TOD is predominantly associated with regional WM volume decreases. Additionally, alongside corroborating previously observed volumetric GM decreases, we provide the first evidence for positive TOD effects. Higher replicability was observed for WM, with the only two replicated GM clusters being volumetric increases in the amygdala and hippocampus, and decreases in the retro-splenial cortex, with the latter more pronounced in individuals with shorter sleep times. These findings implicate the existence of region-specific mechanisms behind GM effects, which might be related to cognitive processes taking place during wakefulness and homeostatic sleep pressure.
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Keywords PL
Keywords EN
Voxel-based morphometry
time-of-day
sleep length
grey matter
white matter
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Wpływ pory dnia na neuronalne mechanizmy leżące u podłoża zniekształceń w pamięci krótkotrwałej wywołanych interferencją o charakterze leksykalnym i przestrzennym - badanie fMRI
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