High-sensitivity cardiac troponin T in detecting obstructive coronary artery disease in hemodialysis patients listed for kidney transplantation

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cris.lastimport.scopus2025-08-30T03:10:16Z
dc.abstract.enBackground: Cardiovascular diseases are the leading cause of morbidity and mortality in patients with end-stage renal disease. Aims: This study aimed to assess the prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) in identifying patients with obstructive coronary artery disease (CAD) among patients on hemodialysis listed for kidney transplantation. Methods: The study prospectively enrolled consecutive adult hemodialysis patients listed for kidney transplantation. They underwent laboratory tests and a standardized set of imaging and functional tests, including coronary angiography, according to patient characteristics. Results: The study included 100 consecutive patients (72 men)at a median age of 56.5 years. Ultimately, 48% of the patients were diagnosed with obstructive CAD. Age and plasma hs-cTnT levels predicted the diagnosis of obstructive CAD (OR, 1.13; 95% CI, 1.08–1.20; P <0.001 and OR, 1.03l 95% CI, 1.01–1.05; P = 0.001, respectively). The calculated cut-off value for age was 53 years, which showed sensitivity of 87.5% and specificity of 76.9% for obstructive CAD diagnosis. The calculated value for hs-cTnT was 0.067 ng/ml, which showed sensitivity of 61.4% and specificity of 82.2% for the detection of obstructive CAD. In patients aged >52 years, 79.2% were diagnosed with obstructive CAD. However, in the group of patients ≤52 years and with hs-cTnT >0.069 ng/ml, the incidence of obstructive CAD was significantly higher than in the group with hs-cTnT level ≤0.069 ng/ml. Conclusions: Baseline hs-cTnT level is a useful prognostic biomarker in the diagnosis of obstructive CAD in hemodialysis patients listed for kidney transplantation.
dc.affiliationInstytut Psychologii
dc.affiliationWydział Projektowania w Warszawie
dc.contributor.authorSzramowska, Agnieszka
dc.contributor.authorBielecki, Maksymilian
dc.contributor.authorGrzeszczyk, Mirosław
dc.contributor.authorŁabyk, Andrzej
dc.contributor.authorKurnicka, Katarzyna
dc.contributor.authorPruszczyk, Piotr
dc.contributor.authorRoik, Marek
dc.date.access2024-03-12
dc.date.accessioned2024-03-26T17:17:13Z
dc.date.available2024-03-26T17:17:13Z
dc.date.created2024-02-22
dc.date.issued2024
dc.description.accesstimeat_publication
dc.description.physical1-7
dc.description.versionfinal_published
dc.identifier.doi10.33963/v.phj.99498
dc.identifier.eissn1897-4279
dc.identifier.issn0022-9032
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/601
dc.identifier.weblinkhttps://journals.viamedica.pl/polish_heart_journal/article/view/99498
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY-NC-ND
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.subject.encardiovascular diseases
dc.subject.enend-stage renal disease
dc.subject.enhemodialysis
dc.subject.enhigh-sensitivity cardiac troponin T
dc.subject.enobstructive coronary artery disease
dc.swps.sciencecloudnosend
dc.titleHigh-sensitivity cardiac troponin T in detecting obstructive coronary artery disease in hemodialysis patients listed for kidney transplantation
dc.title.journalPolish Heart Journal
dc.typeJournalArticle
dspace.entity.typeArticle