Understanding, predicting, and treating depression in pregnancy to improve mothers’ and offspring’s mental health outcomes: The HappyMums Study

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cris.lastimport.scopus2025-08-31T03:12:37Z
dc.abstract.enBackground: Perinatal depression is common: on average, more than 13% of women suffer from physician-diagnosed disorder and 20% report symptoms bearing clinical relevance. Maternal depression not only significantly impacts women’s quality of life but also increases the offspring’s risk of negative developmental outcomes, including mental disorders, through a combination of maternal alterations in in-utero biology and postnatal rearing factors during the early period of life. The HappyMums project aims to improve our understanding of perinatal depression by identifying the factors that robustly predict risk and resilience in mothers and their offspring, determining underlying neurobiological mechanisms, and, finally, testing the efficacy of potential interventions. Methods: HappyMums will use data from a large collection of cohorts and registries containing biological, clinical, socio-demographic, environmental, and lifestyle data. It will pool unique human samples of maternal blood, placenta, chorionic villi and amniotic fluid, analyzing these data alongside pre-clinical samples of brain, blood and placental tissue from models of prenatal stress in mice and livebearing fish for correlative analyses. HappyMums will develop a mobile application (App) to collect multiple data types from women for early screening and monitoring of depressive symptoms. Conclusion: The findings generated by HappyMums will be clinically relevant as they will increase the knowledge on perinatal depression, with unprecedented benefits for the offspring and the society as a whole.
dc.affiliationInstytut Psychologii
dc.affiliationWydział Psychologii w Warszawie
dc.affiliationWydział Psychologii w Sopocie
dc.contributor.authorBiaggi, A.
dc.contributor.authorZonca, V.
dc.contributor.authorAnacker, C.
dc.contributor.authorBegni, V.
dc.contributor.authorBenedetti, F.
dc.contributor.authorBramante, A.
dc.contributor.authorBraniecka, Anna
dc.contributor.authorBrenna, V.
dc.contributor.authorBulgheroni, M.
dc.contributor.authorBuss, C.
dc.contributor.authorCavaliere, L.
dc.contributor.authorCecil, C. A. M.
dc.contributor.authorCouch, A. C.
dc.contributor.authorde Barra, D.
dc.contributor.authorEl Marroun, H.
dc.contributor.authorEntringer, S.
dc.contributor.authorGrassi-Oliveira, R.
dc.contributor.authorJackowska, Marta
dc.contributor.authorKorosi, A.
dc.contributor.authorKwant, P. J. C.
dc.contributor.authorLahti, J.
dc.contributor.authorLekadir, K.
dc.contributor.authorMansuy, I.
dc.contributor.authorManuella, F.
dc.contributor.authorMarizzoni, M.
dc.contributor.authorMeyer, U.
dc.contributor.authorMonk, C.
dc.contributor.authorNakić Radoš, S.
dc.contributor.authorPariante, C. M.
dc.contributor.authorPollux, B. J. A.
dc.contributor.authorPriestley, K.
dc.contributor.authorRäikkönen, K.
dc.contributor.authorRichetto, J.
dc.contributor.authorRiva, M. A.
dc.contributor.authorRothmann, L. M.
dc.contributor.authorSimonetti, V.
dc.contributor.authorVai, B.
dc.contributor.authorVernon, A. C.
dc.contributor.authorŽutić, M.
dc.contributor.authorCattaneo, A.
dc.contributor.authorHappyMums Consortium
dc.date.access2025-02-19
dc.date.accessioned2025-03-03T09:32:55Z
dc.date.available2025-03-03T09:32:55Z
dc.date.created2025-02-02
dc.date.issued2025-02-19
dc.description.accesstimeat_publication
dc.description.grantnumber101057390
dc.description.granttitleHorizon Europe research and innovation programme
dc.description.physical1-10
dc.description.versionfinal_published
dc.description.volume44
dc.identifier.doi10.1016/j.bbih.2025.100961
dc.identifier.issn2666-3546
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1309
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S2666354625000195?via%3Dihub
dc.languageen
dc.language.abstracten
dc.language.subjecten
dc.pbn.affiliationpsychologia
dc.rightsCC-BY-NC-ND
dc.rights.questionYes_rights
dc.share.articleOTHER
dc.subject.plpregnancy
dc.subject.plrisk factors
dc.subject.plperinatal depression
dc.subject.plbiological mechanisms
dc.subject.ploffspring
dc.subject.plintergenerational transmission
dc.swps.sciencecloudnosend
dc.titleUnderstanding, predicting, and treating depression in pregnancy to improve mothers’ and offspring’s mental health outcomes: The HappyMums Study
dc.title.journalBrain, Behavior, & Immunity - Health
dc.typeJournalArticle
dspace.entity.typeArticle