Distinct medial-temporal lobe mechanisms of encoding and amygdala-mediated memory reinstatement for disgust and fear

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cris.lastimport.scopus2025-04-16T03:13:18Z
dc.abstract.enCurrent models of episodic memory posit that retrieval involves the reenactment of encoding processes. Recent evidence has shown that this reinstatement process – indexed by subsequent encoding-retrieval similarity of brain activity patterns - is related to the activity in the hippocampus during encoding. However, we tend to re-experience emotional events in memory more richly than dull events. The role of amygdala - a critical hub of emotion processing – in reinstatement of emotional events was poorly understood. To investigate it, we leveraged a previously overlooked divergence in the role of amygdala in memory modulation by distinct emotions - disgust and fear. Here we used a novel paradigm in which participants encoded complex events (word pairs) and their memory was tested after 3 weeks, both phases during fMRI scanning. Using representational similarity analysis and univariate analyses, we show that the strength of amygdala activation during encoding was correlated with memory reinstatement of individual event representations in emotion-specific regions. Critically, amygdala modulated reinstatement more for disgust than fear. This was in line with other differences observed at the level of memory performance and neural mechanisms of encoding. Specifically, amygdala and perirhinal cortex were more involved during encoding of disgust-related events, whereas hippocampus and parahippocampal gyrus during encoding of fear-related events. Together, these findings shed a new light on the role of the amygdala and medial temporal lobe regions in encoding and reinstatement of specific emotional memories.
dc.affiliationFaculty of Psychology
dc.affiliationInstytut Psychologii
dc.contributor.authorRiegel, Monika
dc.contributor.authorWierzba, Małgorzata
dc.contributor.authorWypych, Marek
dc.contributor.authorRitchey, Maureen
dc.contributor.authorJednoróg, Katarzyna
dc.contributor.authorGrabowska, Anna
dc.contributor.authorVuilleumier, Patrik
dc.contributor.authorMarchewka, Artur
dc.date.access2022-05-01
dc.date.accessioned2024-10-26T09:56:07Z
dc.date.available2024-10-26T09:56:07Z
dc.date.created2022-01-06
dc.date.issued2022-05-01
dc.description.accesstimeat_publication
dc.description.physical1-19
dc.description.versionfinal_published
dc.description.volume251
dc.identifier.doi10.1016/j.neuroimage.2022.118889
dc.identifier.issn1053-8119
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1041
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S1053811922000192
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY-NC-ND
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.swps.sciencecloudnosend
dc.titleDistinct medial-temporal lobe mechanisms of encoding and amygdala-mediated memory reinstatement for disgust and fear
dc.title.journalNeuroImage
dc.typeJournalArticle
dspace.entity.typeArticle