Functional magnetic resonance imaging for the assessment of autonomic dysfunction in patients with antineutrophil cytoplasmic antibody–associated vasculitides

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cris.lastimport.scopus2025-08-31T03:12:52Z
dc.abstract.enINTRODUCTION Nervous system involvement is common in antineutrophil cytoplasmic antibody–associated vasculitides (AAV). While the involvement of the peripheral and central nervous system is well described, it is still unclear how and to what extent the autonomic nervous system (ANS) is affected. Functional magnetic resonance imaging (fMRI) can provide information on both structure and potential damage of the brain, as well as on the function of selected brain centers. OBJECTIVES The aim of this study was to investigate the ANS dysfunction in AAV patients and its correlation with the results of fMRI performed during the Valsalva maneuver. PATIENTS AND METHODS A total of 31 patients with AAV and 30 healthy controls were enrolled in the study. Each participant completed the Composite Autonomic Symptom Score (COMPASS)31 questionnaire. MRI was performed using a 3T scanner. The participants were asked to perform the Valsalva maneuver according to the fixed protocol, and their airway pressure was monitored. During the maneuver, fMRI data were collected. The generalized least squares time series analysis and the region ofinterest (ROI) analysis were subsequently performed. RESULTS The patients with AAV had a higher median COMPASS 31 score than the controls (12.86 vs 2.99, respectively; P <0.01). Structural MRI investigation did not reveal any significant differences between the groups. The brain centers involved in ANS function were detected during fMRI; however, the ROI analysis showed no differences between the study patients and controls. CONCLUSIONS The patients with AAV reported symptoms related to the ANS dysfunction; however, no differences with respect to the functioning of the ANS brain centers were demonstrated between these patients and healthy controls in the fMRI study during the Valsalva maneuver.
dc.affiliationWydział Psychologii, Katowice
dc.contributor.authorWłudarczyk, Anna
dc.contributor.authorDomagalik, Aleksandra
dc.contributor.authorBiedroń, Grzegorz
dc.contributor.authorTutaj, Marcin
dc.contributor.authorŁoboda, Piotr
dc.contributor.authorWawrzycka-Adamczyk, Katarzyna
dc.contributor.authorMarek, Tadeusz
dc.contributor.authorSznajd, Jan
dc.contributor.authorSzczeklik, Wojciech
dc.date.access2023-07-14
dc.date.accessioned2024-01-09T07:20:05Z
dc.date.available2024-01-09T07:20:05Z
dc.date.created2023-07-11
dc.date.issued2023-07-14
dc.description.accesstimeafter_publication
dc.description.issue12
dc.description.physical1-8
dc.description.versionfinal_published
dc.description.volume133
dc.identifier.doi10.20452/pamw.16533
dc.identifier.issn1897-9483
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/216
dc.identifier.weblinkhttps://www.mp.pl/paim/issue/article/16533/
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY-NC-SA
dc.rights.questionYes_rights
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.share.articleOPEN_JOURNAL
dc.subject.enantineutrophil cytoplasmic antibodies
dc.subject.enANCA-associated vasculitides
dc.subject.enautonomic nervous system
dc.subject.enfunctional magnetic resonance imaging
dc.subject.envasculitis
dc.swps.sciencecloudsend
dc.titleFunctional magnetic resonance imaging for the assessment of autonomic dysfunction in patients with antineutrophil cytoplasmic antibody–associated vasculitides
dc.title.journalPolish Archives of Internal Medicine
dc.typeJournalArticle
dspace.entity.typeArticle