Influence of a 2-week transcutaneous auricular vagus nerve stimulation on memory: findings from a randomized placebo controlled trial in non-clinical adults

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cris.lastimport.scopus2025-04-07T03:12:02Z
dc.abstract.enBackground: Memory plays an essential role in daily life and is one of the first functions to deteriorate in cognitive impairment and dementia. Transcutaneous vagus nerve stimulation (tVNS) is a promising therapeutic method, however its ability to enhance memory is underexplored, especially considering long-term stimulation. We aimed to investigate the effect of a 2-week course of auricular tVNS (taVNS) on memory in a non-clinical population. Methods: In the single-blind randomized placebo-waitlist control trial 76 participants (men=30; mean age=48.32) were recruited and randomized into four groups: EARLY ACTIVE/SHAM taVNS and LATE ACTIVE/SHAM taVNS. Participation in the study lasted 4 weeks where EARLY groups underwent 2 weeks intervention immediately following the first study site visit (days 0 to 13) and LATE groups 2 weeks after the first study site visit (days 14 to 27). ACTIVE and SHAM taVNS included 2 weeks of daily 4 hours of neurostimulation at the tragus or earlobe, respectively. To assess memory, we used the Rey Auditory Verbal Learning Test. Results: Two weeks of ACTIVE taVNS, but not SHAM taVNS improved immediate recall and short-term memory score both in EARLY and LATE groups. Furthermore, the improvements persisted over subsequent follow-up in EARLY ACTIVE taVNS. Importantly, the effect of ACTIVE taVNS was superior to SHAM for immediate recall in both EARLY and LATE groups. There were no statistical differences in delayed recall. Conclusion: Our findings suggest that taVNS has potential to improve memory, particularly immediate recall and may be an effective method in preventing memory loss and mitigating cognitive aging.
dc.affiliationWydział Psychologii w Sopocie
dc.affiliationInstytut Psychologii
dc.contributor.authorCibulcova, Veronika
dc.contributor.authorKoenig, Julian
dc.contributor.authorJackowska, Marta
dc.contributor.authorJandackova, Vera Kr
dc.date.access2025-07-22
dc.date.accessioned2024-09-26T09:25:58Z
dc.date.available2024-09-26T09:25:58Z
dc.date.created2024-07-08
dc.date.issued2024-08
dc.description.accesstimeafter_publication
dc.description.grantnumberGACR17-22346Y
dc.description.granttitleCzech Science Foundation
dc.description.physical447-462
dc.description.versionfinal_published
dc.description.volume34
dc.identifier.doi10.1007/s10286-024-01053-0
dc.identifier.eissn1619-1560
dc.identifier.issn0959-9851
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/817
dc.identifier.weblinkhttps://link.springer.com/article/10.1007/s10286-024-01053-0#rightslink
dc.languageen
dc.language.abstracten
dc.pbn.affiliationpsychologia
dc.rightsEmbargo
dc.rights.questionYes_rights
dc.share.articleOTHER
dc.subject.enImmediate recall
dc.subject.enMemory
dc.subject.enMemory modulation
dc.subject.enTranscutaneous vagus nerve stimulation
dc.subject.enVagus nerve
dc.swps.sciencecloudsend
dc.titleInfluence of a 2-week transcutaneous auricular vagus nerve stimulation on memory: findings from a randomized placebo controlled trial in non-clinical adults
dc.title.journalClinical Autonomic Research
dc.typeJournalArticle
dspace.entity.typeArticle