Processing of self-related thoughts in experienced users of classic psychedelics: A source localisation EEG study

StatusVoR
Simple item page
cris.lastimport.scopus2025-04-20T03:12:12Z
dc.abstract.enBackground: Psychedelics have gained increasing interest in scientific research due to their ability to induce profound alterations in perception, emotional processing and self-consciousness. However, the research regarding the functioning of individuals who use psychedelics in naturalistic contexts remains limited. Aims: Here we aim to explore psychological and neurophysiological differences between naturalistic psychedelics users and non-users in terms of processing of self-related thoughts. Methods: We use behavioural testing combined with electroencephalography (EEG) with source localisation. To mitigate potential confounding effects of personality traits and personal history which makes one willing to take psychedelics, we compared users to individuals who did not take psychedelics, but are intending to do so in the future. To ensure robustness of our results, we included two datasets collected at two different laboratories. Results: The results from Dataset I (N = 70) suggest that during self-related thoughts psychedelics users exhibit weaker increases in alpha and beta power in comparison to non-users, primarily in brain regions linked to processing of self-related information and memory (such as posterior cingulate cortex). However, analysis of Dataset II (N = 38) did not replicate the between-group effects, possibly due to the smaller sample size and spatial resolution limitations. Conclusions: While non-replicability restricts interpretation of our findings, our research expands the ongoing discussion on strength and duration of the psychedelic effects, specifically in brain circuits associated with self-related processing, and its relationship to well-being. Our results fit into growing scepticism about the specificity of the role of default-mode network hubs in changes associated with psychedelics experience.
dc.affiliationWydział Psychologii
dc.affiliationWydział Psychologii w Warszawie
dc.affiliationInstytut Psychologii
dc.contributor.authorRuban, Anastasia
dc.contributor.authorMagnuski, Mikołaj
dc.contributor.authorHobot, Justyna
dc.contributor.authorOrłowski, Paweł
dc.contributor.authorKołodziej, Aleksandra
dc.contributor.authorBola, Michał
dc.contributor.authorBrzezicka, Aneta
dc.date.access2025-04-15
dc.date.accessioned2025-04-15T11:20:35Z
dc.date.available2025-04-15T11:20:35Z
dc.date.created2024-11-11
dc.date.issued2025-01-10
dc.description.accesstimeat_publication
dc.description.physical1-16
dc.description.versionfinal_published
dc.description.volume136
dc.identifier.doi10.1016/j.pnpbp.2024.111196
dc.identifier.eissn1878-4216
dc.identifier.issn0278-5846
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1423
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0278584624002641
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsClosedAccess
dc.rights.explanationzamknięty dostęp
dc.rights.questionNo_rights
dc.share.articleOPEN_REPOSITORY
dc.subject.enPsychedelics
dc.subject.enElectroencephalography
dc.subject.enSelf-related thoughts
dc.subject.enSelf-consiousness
dc.swps.sciencecloudsend
dc.titleProcessing of self-related thoughts in experienced users of classic psychedelics: A source localisation EEG study
dc.title.journalProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.typeJournalArticle
dspace.entity.typeArticle