Do Diabetes and Genetic Polymorphisms in the COMT and OPRM1 Genes Modulate the Postoperative Opioid Demand and Pain Perception in Osteoarthritis Patients After Total Knee and Hip Arthroplasty?

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cris.lastimport.scopus2025-08-31T03:12:24Z
dc.abstract.enBackground: Osteoarthritis (OA) of the hip and knee is a common age-related degenerative disease characterized by joint pain, stiffness, and gait disturbances. This study investigated the influence of genetic polymorphisms in the OPRM1 (rs1799971) and COMT (rs4633, rs4680, rs4818, and rs6269) genes on the postoperative analgesic requirements in 195 diabetic and non-diabetic patients undergoing total hip or knee arthroplasty. Methods: The prospective study included all patients who were admitted between January and September 2020 and agreed to participate. Postoperative pain management was assessed based on acetaminophen, ketoprofen, and morphine consumption on the first and second postoperative day. Results: Multilevel regression analyses revealed a significant three-way interaction between diabetes, type of analgesic, and OPRM1rs1799971 polymorphism, indicating different analgesic dosing patterns in diabetic and non-diabetic patients. Two-way interactions between diabetes and COMT polymorphisms rs4633, rs4680, and rs6269 further influenced the analgesic requirements. No significant associations were found for COMT rs4818. The results show that diabetes and genetic factors significantly influence opioid requirements and pain perception. Conclusions: Given the complexity of pain management in diabetic patients, personalized analgesic strategies tailored to genetic and metabolic profiles could be useful in postoperative pain management and reducing opioid consumption.
dc.affiliationWydział Psychologii we Wrocławiu
dc.affiliationInstytut Psychologii
dc.contributor.authorJurewicz, Alina
dc.contributor.authorGąsiorowska, Agata
dc.contributor.authorLeźnicka, Katarzyna
dc.contributor.authorMaciejewska-Skrendo, Agnieszka
dc.contributor.authorPawlak, Maciej
dc.contributor.authorMachoy-Mokrzyńska, Anna
dc.contributor.authorBohatyrewicz, Andrzej
dc.contributor.authorTarnowski, Maciej
dc.date.access2025-06-30
dc.date.accessioned2025-07-02T07:06:08Z
dc.date.available2025-07-02T07:06:08Z
dc.date.created2025-06-28
dc.date.issued2025-06-30
dc.description.abstract<jats:p>Background: Osteoarthritis (OA) of the hip and knee is a common age-related degenerative disease characterized by joint pain, stiffness, and gait disturbances. This study investigated the influence of genetic polymorphisms in the OPRM1 (rs1799971) and COMT (rs4633, rs4680, rs4818, and rs6269) genes on the postoperative analgesic requirements in 195 diabetic and non-diabetic patients undergoing total hip or knee arthroplasty. Methods: The prospective study included all patients who were admitted between January and September 2020 and agreed to participate. Postoperative pain management was assessed based on acetaminophen, ketoprofen, and morphine consumption on the first and second postoperative day. Results: Multilevel regression analyses revealed a significant three-way interaction between diabetes, type of analgesic, and OPRM1rs1799971 polymorphism, indicating different analgesic dosing patterns in diabetic and non-diabetic patients. Two-way interactions between diabetes and COMT polymorphisms rs4633, rs4680, and rs6269 further influenced the analgesic requirements. No significant associations were found for COMT rs4818. The results show that diabetes and genetic factors significantly influence opioid requirements and pain perception. Conclusions: Given the complexity of pain management in diabetic patients, personalized analgesic strategies tailored to genetic and metabolic profiles could be useful in postoperative pain management and reducing opioid consumption</jats:p>
dc.description.accesstimeat_publication
dc.description.issue13
dc.description.physical1-20
dc.description.versionfinal_published
dc.description.volume14
dc.identifier.doi10.3390/jcm14134634
dc.identifier.issn2077-0383
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1568
dc.identifier.weblinkhttps://www.mdpi.com/2077-0383/14/13/4634
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.subject.enCOMT
dc.subject.enOPRM1
dc.subject.enpolymorphism
dc.subject.enpain
dc.subject.enpostoperative treatment
dc.subject.enopioids
dc.subject.endiabetes
dc.swps.sciencecloudsend
dc.titleDo Diabetes and Genetic Polymorphisms in the COMT and OPRM1 Genes Modulate the Postoperative Opioid Demand and Pain Perception in Osteoarthritis Patients After Total Knee and Hip Arthroplasty?
dc.title.journalJournal of Clinical Medicine
dc.typeJournalArticle
dspace.entity.typeArticle