Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group

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cris.lastimport.scopus2025-05-05T03:14:20Z
dc.abstract.plObjective: Specific phobia is a common anxiety disorder, but the literature on associated brain structure alterations exhibits substantial gaps. The ENIGMA Anxiety Working Group examined brain structure differences between individuals with specific phobias and healthy control subjects as well as between the animal and blood-injection-injury (BII) subtypes of specific phobia. Additionally, the authors investigated associations of brain structure with symptom severity and age (youths vs. adults). Methods: Data sets from 31 original studies were combined to create a final sample with 1,452 participants with phobia and 2,991 healthy participants (62.7% female; ages 5–90). Imaging processing and quality control were performed using established ENIGMA protocols. Subcortical volumes as well as cortical surface area and thickness were examined in a preregistered analysis. Results: Compared with the healthy control group, the phobia group showed mostly smaller subcortical volumes, mixed surface differences, and larger cortical thickness across a substantial number of regions. The phobia subgroups also showed differences, including, as hypothesized, larger medial orbitofrontal cortex thickness in BII phobia (N=182) compared with animal phobia (N=739). All findings were driven by adult participants; no significant results were observed in children and adolescents. Conclusions: Brain alterations associated with specific phobia exceeded those of other anxiety disorders in comparable analyses in extent and effect size and were not limited to reductions in brain structure. Moreover, phenomenological differences between phobia subgroups were reflected in diverging neural underpinnings, including brain areas related to fear processing and higher cognitive processes. The findings implicate brain structure alterations in specific phobia, although subcortical alterations in particular may also relate to broader internalizing psychopathology.
dc.affiliationWydział Psychologii i Prawa w Poznaniu
dc.affiliationInstytut Psychologii
dc.contributor.authorHilbert, Kevin
dc.contributor.authorBoeken, Ole Jonas
dc.contributor.authorLanghammer, Till
dc.contributor.authorGroenewold, Nynke A.
dc.contributor.authorBas-Hoogendam, Janna Marie
dc.contributor.authorAghajani, Moji
dc.contributor.authorZugman, André
dc.contributor.authorÅhs, Fredrik
dc.contributor.authorArolt, Volker
dc.contributor.authorBeesdo-Baum, Katja
dc.contributor.authorBjörkstrand, Johannes
dc.contributor.authorBlackford, Jennifer U.
dc.contributor.authorBlanco-Hinojo, Laura
dc.contributor.authorBöhnlein, Joscha
dc.contributor.authorBülow, Robin
dc.contributor.authorCano, Marta
dc.contributor.authorCardoner, Narcis
dc.contributor.authorCaseras, Xavier
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDomschke, Katharina
dc.contributor.authorFehm, Lydia
dc.contributor.authorFeola, Brandee
dc.contributor.authorFredrikson, Mats
dc.contributor.authorGoossens, Liesbet
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorGur, Raquel E.
dc.contributor.authorHamm, Alfons O.
dc.contributor.authorHarrewijn, Anita
dc.contributor.authorHeinig, Ingmar
dc.contributor.authorHerrmann, Martin J.
dc.contributor.authorHofmann, David
dc.contributor.authorJackowski, Andrea P.
dc.contributor.authorJansen, Andreas
dc.contributor.authorKaczkurkin, Antonia N.
dc.contributor.authorKindt, Merel
dc.contributor.authorKingsley, Ellen N.
dc.contributor.authorKircher, Tilo
dc.contributor.authorKlahn, Anna L.
dc.contributor.authorKoelkebeck, Katja
dc.contributor.authorKrug, Axel
dc.contributor.authorKugel, Harald
dc.contributor.authorLarsen, Bart
dc.contributor.authorLeehr, Elisabeth J.
dc.contributor.authorLeonhardt, Lieselotte
dc.contributor.authorLotze, Martin
dc.contributor.authorMargraf, Jürgen
dc.contributor.authorMichałowski, Jarosław
dc.contributor.authorMuehlhan, Markus
dc.contributor.authorNenadić, Igor
dc.contributor.authorPan, Pedro M.
dc.contributor.authorPauli, Paul
dc.contributor.authorPeñate, Wenceslao
dc.contributor.authorPittig, Andre
dc.contributor.authorPlag, Jens
dc.contributor.authorPujol, Jesus
dc.contributor.authorRichter, Jan
dc.contributor.authorRivero, Francisco L.
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorSatterthwaite, Theodore D.
dc.contributor.authorSchäfer, Axel
dc.contributor.authorSchäfer, Judith
dc.contributor.authorSchienle, Anne
dc.contributor.authorSchneider, Silvia
dc.contributor.authorSchrammen, Elisabeth
dc.contributor.authorSchruers, Koen
dc.contributor.authorSchulz, Stefan M.
dc.contributor.authorSeidl, Esther
dc.contributor.authorStark, Rudolf M.
dc.contributor.authorStein, Frederike
dc.contributor.authorStraube, Benjamin
dc.contributor.authorStraube, Thomas
dc.contributor.authorStröhle, Andreas
dc.contributor.authorSuchan, Boris
dc.contributor.authorThomopoulos, Sophia I.
dc.contributor.authorVentura-Bort, Carlos
dc.contributor.authorVisser, Renee
dc.contributor.authorVölzke, Henry
dc.contributor.authorWabnegger, Albert
dc.contributor.authorWannemüller, André
dc.contributor.authorWendt, Julia
dc.contributor.authorWiemer, Julian
dc.contributor.authorWittchen, Hans-Ulrich
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWright, Barry
dc.contributor.authorYang, Yunbo
dc.contributor.authorZilverstand, Anna
dc.contributor.authorZwanzger, Peter
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorWinkler, Anderson M.
dc.contributor.authorPine, Daniel S.
dc.contributor.authorJahanshad, Neda
dc.contributor.authorThompson, Paul M.
dc.contributor.authorStein, Dan J.
dc.contributor.authorVan der Wee, Nic J. A.
dc.contributor.authorLueken, Ulrike
dc.date.access2024-09-10
dc.date.accessioned2024-09-11T08:35:30Z
dc.date.available2024-09-11T08:35:30Z
dc.date.created2024-06-11
dc.date.issued2024-06-11
dc.description.accesstimeafter_publication
dc.description.grantnumberDEC-2011/03/D/HS6/05951
dc.description.grantnumberDEC-2011/03/D/HS6/05578
dc.description.issue8
dc.description.physical728–740
dc.description.versionfinal_author
dc.description.volume181
dc.identifier.doi10.1176/appi.ajp.20230032
dc.identifier.issn0002-953X
dc.identifier.issn1535-7228
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/861
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.explanationNie mam pojęcia czy to osiągnięcie może być deponowane. Uprzejmie proszę o sprawdzenie tego.
dc.rights.questionYes_rights
dc.share.articleOTHER
dc.subject.enspecific phobia
dc.subject.enanimal phobia
dc.subject.enblood-Injection-Injury phobia
dc.subject.enstructural neuroimaging
dc.subject.enmegaanalysis
dc.subject.enENIGMA
dc.swps.sciencecloudsend
dc.titleCortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group
dc.title.journalAmerican Journal of Psychiatry
dc.typeJournalArticle
dspace.entity.typeArticle