Shared and distinct alterations in brain structure of youth with internalizing or externalizing disorders : Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups

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cris.lastimport.scopus2025-08-27T03:15:43Z
dc.abstract.enBackground: Externalizing and internalizing disorders are common in youth but are often studied separately, preventing researchers from identifying shared (i.e., transdiagnostic) alterations in brain structure. Using data from the ENIGMA Consortium, we conducted a mega-analysis to identify shared and distinct cortical and subcortical brain alterations across internalizing (anxiety disorders and depression) and externalizing disorders (attentiondeficit/hyperactivity disorder [ADHD] and conduct disorder [CD]) in youth. Methods: 3D T1-weighted MRI data from youth (aged 4-21 years) with anxiety disorders (n=1,044), depression (n=504), ADHD (n=1,317), and CD (n=1,172), along with healthy controls (n=4,743) were analyzed. We assessed group differences in regional cortical thickness, surface area, and subcortical volume using linear models, adjusted for site, age, and sex, and total intracranial volume in the surface area and subcortical volume models. Results: We observed transdiagnostic associations, with both internalizing and externalizing disorders characterized by lower surface area in the insula, entorhinal cortex, and middle temporal gyrus, and lower amygdala volume (Cohen’s ds=-0.07 to -0.24), as well as total surface area and intracranial volume (ds=-0.11 to -0.25). Externalizing-specific reductions in surface area were observed in fronto-parietal regions (ds=-0.08 to -0.13), but no internalizing-specific associations were identified. Disorder-specific alterations were identified for ADHD, CD, and anxiety disorders, but not depression. Conclusions: Both common and disorder-specific alterations were identified, with regions involved in salience attribution and emotion processing implicated across internalizing and externalizing disorders. These findings can guide future research targeting common biological processes across youth psychiatric disorders as well as features unique to individual disorders.
dc.affiliationLaboratorium Neuronauki Emocji, Wydział Psychologii i Prawa w Poznaniu
dc.affiliationWydział Psychologii i Prawa w Poznaniu
dc.affiliationInstytut Psychologii
dc.contributor.authorMichałowski, Jarosław
dc.contributor.authorStaginnus, Marlene
dc.contributor.authorGao, Yidian
dc.contributor.authorAlexander, Nina
dc.contributor.authorArolt, Volker
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBellgrove, Mark A.
dc.contributor.authorBenegal, Vivek
dc.contributor.authorBlair, Robert J.
dc.contributor.authorBlanco-Hinojo, Laura
dc.contributor.authorBoeken, Ole Jonas
dc.contributor.authorBöhnlein, Joscha
dc.contributor.authorBölte, Sven
dc.contributor.authorBonnekoh, Linda M.
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorBressan, Rodrigo A.
dc.contributor.authorBreuer, Fabian
dc.contributor.authorBruin, Willem B.
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorBurkhouse, Katie L.
dc.contributor.authorCalkins, Monica E.
dc.contributor.authorCano, Marta
dc.contributor.authorCardoner, Narcis
dc.contributor.authorChen, Hui
dc.contributor.authorChen, Xianliang
dc.contributor.authorCoghill, David R.
dc.contributor.authorColins, Olivier F.
dc.contributor.authorConnolly, Colm G.
dc.contributor.authorCraig, Michael C.
dc.contributor.authorCullen, Kathryn R.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDavey, Christopher G.
dc.contributor.authorDietrich, Andrea
dc.contributor.authorDong, Daifeng
dc.contributor.authorFreitag, Christine M.
dc.contributor.authorFrodl, Thomas
dc.contributor.authorGoossens, Liesbet
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorGur, Raquel E.
dc.contributor.authorGur, Ruben C.
dc.contributor.authorHaavik, Jan
dc.contributor.authorHagan, Cindy C.
dc.contributor.authorHahn, Tim
dc.contributor.authorHamm, Alfons O.
dc.contributor.authorHarrison, Ben J.
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHerrmann, Martin J.
dc.contributor.authorHo, Tiffany C.
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHolla, Bharath
dc.contributor.authorIbrahim, Karim
dc.contributor.authorJackowski, Andrea
dc.contributor.authorJamalabadi, Hamidreza
dc.contributor.authorJiang, Yali
dc.contributor.authorKircher, Tilo
dc.contributor.authorKonrad, Kerstin
dc.contributor.authorKraus, Anna
dc.contributor.authorKuntsi, Jonna
dc.contributor.authorLanghammer, Till
dc.contributor.authorLazaro, Luisa
dc.contributor.authorLeehr, Elisabeth J.
dc.contributor.authorLueken, Ulrike
dc.contributor.authorMa, Ren
dc.contributor.authorMacMaster, Frank P.
dc.contributor.authorManfro, Gisele G.
dc.contributor.authorMartinelli, Anne
dc.contributor.authorMeinert, Hannah
dc.contributor.authorMeinert, Susanne
dc.contributor.authorTownend, Sophie
dc.contributor.authorMing, Qingsen
dc.contributor.authorMoeck, Robert
dc.contributor.authorMujica-Parodi, Lilianne R.
dc.contributor.authorMwangi, Benson
dc.contributor.authorNeufeld, Janina
dc.contributor.authorNigg, Joel T.
dc.contributor.authorO’Gorman Tuura, Ruth L.
dc.contributor.authorOh, Hyuntaek
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorPaloyelis, Yannis
dc.contributor.authorPan, Pedro M.
dc.contributor.authorPassamonti, Luca
dc.contributor.authorPeñate, Wenceslao
dc.contributor.authorPhan ,K. Luan
dc.contributor.authorPlessen, Kerstin J.
dc.contributor.authorPujol, Jesus
dc.contributor.authorRemnélius, Karl Lundin
dc.contributor.authorRivero, Francisco
dc.contributor.authorRubia, Katya
dc.contributor.authorSalas, Ramiro
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorSatterthwaite, Theodore D.
dc.contributor.authorSchienle, Anne
dc.contributor.authorSchrammen, Elisabeth
dc.contributor.authorSchruers, Koen R.J.
dc.contributor.authorSchumann, Gunter
dc.contributor.authorSethi, Arjun
dc.contributor.authorSilk, Tim
dc.contributor.authorSkokauskas, Norbert
dc.contributor.authorSmoller, Jordan
dc.contributor.authorSoares, Jair C.
dc.contributor.authorSørensen, Lin
dc.contributor.authorStadler, Christina
dc.contributor.authorStevens, Michael C.
dc.contributor.authorStraube, Benjamin
dc.contributor.authorStraube, Thomas
dc.contributor.authorStröhle, Andreas
dc.contributor.authorSudre, Gustavo
dc.contributor.authorSukhodolsky, Denis G.
dc.contributor.authorSully, Kate
dc.contributor.authorSun, Xiaoqiang
dc.contributor.authorSylvester, Chad M.
dc.contributor.authorToschi, Nicola
dc.contributor.authorvan der Werff, Steven J.A.
dc.contributor.authorVance, Alasdair
dc.contributor.authorVermeiren, Robert
dc.contributor.authorWabnegger, Albert
dc.contributor.authorWang, Xiaoping
dc.contributor.authorWendt, Julia
dc.contributor.authorWhittle, Sarah
dc.contributor.authorWiemer, Julian
dc.contributor.authorWinkler, Anderson M.
dc.contributor.authorWittchen, Hans U.
dc.contributor.authorWu, Mon-Ju
dc.contributor.authorWu, Qiong
dc.contributor.authorYang, Tony T.
dc.contributor.authorYang, Yunbo
dc.contributor.authorYao, Shuqiao
dc.contributor.authorZhang, Jibiao
dc.contributor.authorZhou, Jiansong
dc.contributor.authorZugman, Andre
dc.contributor.authorZunta-Soares, Giovana B.
dc.contributor.authorZwanzger, Peter M.
dc.contributor.authorThomopoulos, Sophia I.
dc.contributor.authorJahanshad, Neda
dc.contributor.authorThompson, Paul M.
dc.contributor.authorHilbert, Kevin
dc.contributor.authorBaskin-Sommers, Arielle
dc.contributor.authorCecil, Charlotte A.M.
dc.contributor.authorAghajani, Moji
dc.contributor.authorPine, Daniel S.
dc.contributor.authorvan der Wee, Nic J.A.
dc.contributor.authorStein, Dan J.
dc.contributor.authorGroenewold, Nynke A.
dc.contributor.authorBas-Hoogendam, Janna Marie
dc.contributor.authorHan, Laura K.M.
dc.contributor.authorPozzi, Elena
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorFranke, Barbara
dc.contributor.authorHoogman, Martine
dc.contributor.authorWalton, Esther
dc.contributor.authorDe Brito, Stephane A.
dc.contributor.authorFairchild, Graeme
dc.date.access2025-08-22
dc.date.accessioned2025-08-22T09:10:24Z
dc.date.available2025-08-22T09:10:24Z
dc.date.created2025-08-04
dc.date.issued2025-08-12
dc.description.accesstimebefore_publication
dc.description.versionfinal_published
dc.identifier.doi10.1016/j.biopsych.2025.08.003
dc.identifier.issn0006-3223
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1703
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY-NC-ND
dc.rights.questionYes_rights
dc.share.articleOPEN_JOURNAL
dc.subject.enTransdiagnostic
dc.subject.enChild and adolescent psychiatry
dc.subject.enENIGMA
dc.subject.enStructural MRI
dc.subject.enMeta-analysis
dc.subject.enYouth
dc.swps.sciencecloudnosend
dc.titleShared and distinct alterations in brain structure of youth with internalizing or externalizing disorders : Findings from the ENIGMA Antisocial Behavior, ADHD, MDD, and Anxiety Working Groups
dc.title.journalBiological Psychiatry
dc.typeJournalArticle
dspace.entity.typeArticle