Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients

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cris.lastimport.scopus2025-08-31T03:16:06Z
dc.abstract.enIntroduction: Schizophrenia (SZ) and bipolar disorder (BD) share common clinical features, symptoms, and neurocognitive deficits, which results in common misdiagnosis. Recently, it has been suggested that alterations within brain networks associated with perceptual organization yield potential to distinguish SZ and BD individuals. The aim of our study was to evaluate whether functional connectivity (FC) of the dorsal attention network (DAN) may differentiate both conditions. Methods: The study involved 90 participants: 30 remitted SZ patients, 30 euthymic BD patients, and 30 healthy controls (HC). Resting state functional magnetic resonance imaging was used to compare the groups in terms of the FC within the core nodes of the DAN involving frontal eye fields (FEF) and intraparietal sulcus (IPS). Results: BD patients presented weaker inter-hemispheric FC between right and left FEF than HC. While SZ did not differ from HC in terms of inter-FEF connectivity, they presented increased inter- and intra-hemispheric FC between FEF and IPS. When compared with BD, SZ patients showed increased FC between right FEF and other nodes of the network (bilateral IPS and left FEF). Conclusion: We have shown that altered resting state FC within DAN differentiates BD, SZ, and HC groups. Divergent pattern of FC within DAN, consisting of hypoconnectivity in BD and hyperconnectivity in SZ, might yield a candidate biomarker for differential diagnosis between both conditions. More highly powered studies are needed to confirm these possibilities.
dc.affiliationWydział Psychologii Katowice
dc.contributor.authorChrobak, Adrian Andrzej
dc.contributor.authorBielak, Sylwia
dc.contributor.authorNowaczek, Dominik
dc.contributor.authorŻyrkowska, Aleksandra
dc.contributor.authorSobczak, Anna Maria
dc.contributor.authorFafrowicz, Magdalena
dc.contributor.authorBryll, Amira
dc.contributor.authorMarek, Tadeusz
dc.contributor.authorDudek, Dominika
dc.contributor.authorSiwek, Marcin
dc.date.access2024-09-19
dc.date.accessioned2024-09-20T09:00:19Z
dc.date.available2024-09-20T09:00:19Z
dc.date.created2024-08-26
dc.date.issued2024-09-19
dc.description.accesstimeat_publication
dc.description.grantnumber2017/27/N/NZ4/00771
dc.description.granttitleBadanie strukturalnych i funkcjonalnych neurokorelatów nowo odkrytych zaburzeń nieświadomego uczenia się motorycznego u pacjentów ze schizofrenią i chorobą afektywną dwubiegunową
dc.description.physical1-9
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3389/fpsyt.2024.1474313
dc.identifier.issn1664-0640
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/875
dc.identifier.weblinkhttps://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1474313/full
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.rights.urihttps://creativecommons.org/licenses/by/3.0
dc.share.articleOPEN_JOURNAL
dc.subject.enparietal cortex
dc.subject.enfrontal eye fields
dc.subject.enresting state
dc.subject.enfunctional networks
dc.subject.enschizophrenia
dc.subject.enbipolar disorder
dc.swps.sciencecloudsend
dc.titleDivergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients
dc.title.journalFrontiers in Psychiatry
dc.typeJournalArticle
dspace.entity.typeArticle