Exploring DMT: Endogenous role and therapeutic potential

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cris.lastimport.scopus2025-05-09T03:10:14Z
dc.abstract.enN,N-Dimethyltryptamine (DMT) is a naturally occurring amine and psychedelic compound, found in plants, animals, and humans. While initial studies reported only trace amounts of DMT in mammalian brains, recent findings have identified alternative methylation pathways and DMT levels comparable to classical neurotransmitters in rodent brains, calling for a re-evaluation of its biological role and exploration of this inconsistency. This study evaluated DMT's biosynthetic pathways, focusing on indolethylamine N-methyltransferase (INMT) and its isoforms, and possible regulatory mechanisms, including alternative routes of synthesis and how physiological conditions, such as stress and hypoxia influence DMT levels. This review considers the impact of endogenous regulatory factors on DMT synthesis and degradation, particularly under conditions affecting monoamine oxidase (MAO) efficiency and activity. We also examined DMT's potential roles in various physiological processes, including neuroplasticity and neurogenesis, mitochondrial homeostasis, immunomodulation, and protection against hypoxia and oxidative stress. DMT's lipophilic properties allow it to cross cell membranes and activate intracellular 5-HT2A receptors, contributing to its role in neuroplasticity. This suggests DMT may act as an endogenous ligand for intracellular receptors, highlighting its broader biological significance beyond traditional receptor pathways. The widespread evolutionary presence of DMT's biosynthetic pathways across diverse species suggests it may play essential roles in various developmental stages and cellular adaptation to environmental challenges, highlighting the neurobiological significance of DMT and its potential clinical applications. We propose further research to explore the role of endogenous DMT, particularly as a potential neurotransmitter.
dc.affiliationWydział Psychologii w Warszawie
dc.affiliationInstytut Psychologii
dc.contributor.authorSchimmelpfennig, Jakub
dc.contributor.authorJankowiak-Siuda, Kamila
dc.date.access2025-05-01
dc.date.accessioned2025-05-08T13:34:40Z
dc.date.available2025-05-08T13:34:40Z
dc.date.created2025-01-16
dc.date.issued2025-05-01
dc.description.accesstimeat_publication
dc.description.physical1-18
dc.description.versionfinal_published
dc.description.volume268
dc.identifier.doi10.1016/j.neuropharm.2025.110314
dc.identifier.issn0028-3908
dc.identifier.urihttps://share.swps.edu.pl/handle/swps/1448
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0028390825000206?via%3Dihub
dc.languageen
dc.pbn.affiliationpsychologia
dc.rightsCC-BY
dc.rights.questionYes_rights
dc.share.articleOTHER
dc.subject.enDMT
dc.subject.enNeuroplasticity
dc.subject.enNeuroprotection
dc.subject.enAnti-inflammation
dc.subject.enHypoxia
dc.subject.enINMT
dc.subject.enPsychedelics
dc.swps.sciencecloudsend
dc.titleExploring DMT: Endogenous role and therapeutic potential
dc.title.journalNeuropharmacology
dc.typeJournalArticle
dspace.entity.typeArticle