Rats respond to aversive emotional arousal of human handlers with the activation of the basolateral and central amygdala

StatusPost-Print
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Authors
Kaźmierowska, Anna M.
Kostecki, Mateusz
Szczepanik, Michał
Nikolaev, Tomasz
Hamed, Adam
Michałowski, Jarosław
Wypych, Marek
Marchewka, Artur
Knapska, Ewelina
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Date
2023-11-07
Publisher
Journal title
Proceedings of the National Academy of Sciences
Issue
46
Volume
120
Pages
Pages
1-9
DOI
ISSN
0027-8424
1091-6490
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Access date
2023-11-10
Abstract PL
Abstract EN
Reading danger signals may save an animal’s life, and learning about threats from others allows avoiding first- hand aversive and often fatal experiences. Fear expressed by other individuals, including those belonging to other species, may indicate the presence of a threat in the environment and is an important social cue. Humans and other animals respond to conspecifics’ fear with increased activity of the amygdala, the brain struc-ture crucial for detecting threats and mounting an appropriate response to them. It is unclear, however, whether the cross- species transmission of threat information involves similar mechanisms, e.g., whether animals respond to the aversively induced emotional arousal of humans with activation of fear- processing circuits in the brain. Here, we report that when rats interact with a human caregiver who had recently undergone fear conditioning, they show risk assessment behavior and enhanced amygdala activation. The amygdala response involves its two major parts, the basolateral and central, which detect a threat and orchestrate defensive responses. Further, we show that humans who learn about a threat by observing another aversively aroused human, similar to rats, activate the basolateral and centromedial parts of the amygdala. Our results demonstrate that rats detect the emotional arousal of recently aversively stimulated caregivers and suggest that cross- species social transmission of threat information may involve similar neural circuits in the amygdala as the within- species transmission.
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Keywords PL
Keywords EN
social transmission of threat information
basolateral amygdala
centromedial amygdala
cross- species
interspecies
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URI
https://share.swps.edu.pl/handle/swps/142
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cc-by-nc-nd
Except as otherwise noted, this item is licensed under the Attribution-NonCommercial-NoDerivatives licence | Permitted use of copyrighted works
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